Research

Immune System and Defense Mechanisms of Aquatic Organisms
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Molecular Biology Defense Mechanisms Host-Pathogen Interactions

We are elucidating the defense mechanisms of fish and crustaceans. By analyzing host responses to pathogens at the molecular and cellular levels, and through the identification and expression analysis of immune-related genes, we aim to clarify the overall picture of the immune system unique to aquatic organisms.

Invertebrates such as shrimp do not possess antibody-mediated adaptive immunity and cope with pathogens using only innate immunity. Elucidating this sophisticated mechanism is a critical research theme directly linked to disease control in aquaculture.

Related Theses

Decoding Biological Information via Advanced Genome/Omics Analysis
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Genome Sequencing Single-cell Analysis Bioinformatics

We are engaged in whole-genome analysis and single-cell RNA-seq analysis using Next-Generation Sequencers (NGS). Utilizing Oxford Nanopore GridION and Illumina MiSeq, we unravel vast amounts of biological information through bioinformatics.

We perform de novo genome sequencing of non-model organisms to comprehensively identify immune-related gene groups and reveal fluctuations in gene expression at the tissue and cellular levels.

Related Theses

Disease Control through Regulation and Utilization of Microorganisms
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Probiotics Intestinal Microbiota Disease Diagnosis Vaccines

We are working on immune stimulation by mixing beneficial bacteria (probiotics) into feed, vaccine development, and establishing rapid diagnostic methods. We aim to prevent and control bacterial and viral diseases that are problematic in aquaculture sites.

Through the analysis of microbiota, we evaluate the effects of probiotics on host immune functions and promote the development of sustainable aquaculture technologies that do not rely on chemical drugs.